Yup, well my current one is Buffy the Vampire Slayer
Before Twilight, True Blood, The Vampire Diaries there was Buffy. Full of witty one-liners, some very fanciable Vampires (and non-vampires!) and numerous Demons who're determined to take over the world, from the Hell-Mouth which sits just under Sunnydale High School!
Really, if you've not seen any of it before go and take a peek!